Thanks X. At work I've actually used the Snappy in the past, maybe something like over 10 years ago, we had video cameras on optical microscopes. Now we use Canon MKII(n) cameras on those same scopes (metallurgical and stereo). Last week I did a test by averaging 16 MKII raw shots that were taken at ISO1600 and there was quite a lot of visible improvement (according to the theory the signal to noise ratio could improve up to sqr(N) times where N is the number of frames, provided that certain boundary conditions are fulfilled). We have the programmable Canon remote controller on this camera so taking the 16 shots, even with the mirror-up-first method, is very easy, just a press on the start button. But the whole process (from the start button on the remote to the final 16 shot average result) took as much as 15 minutes.
We btw have at the lab many imaging systems that employ frame averaging (among many other noise suppression techniques), e.g. a scanning electron microscope that does up to 8000 frames, an X-ray spay imaging system that has a video camera and does up to 256 frames and an EDS material analyzer ( it also collects images) and has no frame count limit.
I also took 16 X-ray images (that themselves were already 256 averages by that system). Averaging those 16 images did not give any visible benefit at all and only a very very small improvement by difference mode comparison.